Advances in modeling and comparative genomics hold promise of a better understanding of the evolution of the self- organizing cytoskeleton in early eukaryotes, and its role in the evolution of novel eukaryotic functions, such as amoeboid motility, mitosis, and ciliary swimming. The evolution of new aspects of filament dynamics in eukaryotes, including severing and branching, and the advent of molecular motors converted the eukaryotic cytoskeleton into a self- organizing "active gel," the dynamics of which can only be described with computational models. Here, the dynamic properties of the prokaryotic and eukaryotic cytoskeleton are compared, and how these relate to function and evolution of organellar networks is discussed. Prokaryotic filament systems show bewildering structural and dynamic complexity and, in many aspects, prefigure the self- organizing properties of the eukaryotic cytoskeleton. The eukaryotic cytoskeleton evolved from prokaryotic cytomotive filaments. Origin and evolution of the self- organizing cytoskeleton in the network of eukaryotic organelles. However, it should be recognized that the concept of “master†and “servant†cell components is a metaphor in present-day living organisms their organellar components are considered to be interdependent and inseparable.
Our proposal is that maternal mitochondria are the selfish “master†entities of the eukaryotic cell with respect not only to their propagation from cell-to-cell and from generation-to-generation but also to their regulation of all other cellular functions. Thus, it is proposed that the “selfish gene†hypothesis of Dawkins1 is not the only possible perspective for comprehending genomic and cellular evolution. The present paper discusses how the endosymbiotic theory implicates a new hypothesis about the hierarchical and communicational organization of the integrated prokaryotic components of the eukaryotic cell and provides a new angle from which to consider the theory of evolution and its bearing upon cellular complexity. This new perspective on the organization of the cell has been further expanded to reveal the concept of a public milieu, the cytosol, in which Energides and mitochondria live, each with their own private internal milieu. Mitochondria represent one of these types of previously independent organisms, the Energide, is another type.
Some of these units were originally free-living prokaryotes, which were engulfed during evolutionary time. The Energide concept, as well as the endosymbiotic theory of eukaryotic cell organization and evolution, proposes that present-day cells of eukaryotic organisms are mosaics of specialized and cooperating units, or organelles. Before that, she was a Genetics Associate at Genzyme Genetics (now LabCorp) where she was responsible for coordinating genetic testing and analysis.Are maternal mitochondria the selfish entities that are masters of the cells of eukaryotic multicellular organisms?īarlow, Peter W Baldelli, E BaluÅ¡ka, Frantisek Previously, she served in various roles for the Office of Technology Licensing at Stanford University, including licensing, managing special projects and leading the technical marketing team.
Prior to joining the Jain Foundation in 2021, she established the technical marketing program for the Office of Technology Management at Washington University in St. Primiano has extensive experience in university technology transfer, helping to move promising inventions from the bench to the bedside. She contributes to the strategic direction of the Jain Foundation and works with the Scientific Advisory Board to develop and supervise a portfolio of dysferlinopathy research projects and patient programs. degree in Biology from the Massachusetts Institute of Technology. degree in Human Genetics (Genetic Counseling Track) from VCU School of Medicine and her B.S.
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